The review presents generalized literature data on red raspberry (Rubus idaeus L.) leaves as a promising natural source for obtaining pharmaceutical substances for further development of medicines. Indicators of purity and morphological characteristics of R. idaeus leaves are described: loss on drying — 12.25 ± 0.07%; ash insoluble in hydrochloric acid — 0.29 ± 0.18%; content of extractives with 50% ethanol as solvent — 43.95%. The chemical composition of R. idaeus leaves is shown. R. idaeus leaves contain saponins, salicylic, lactic and succinic acids; phytonicides; macronutrients and trace elements. Mucilage, protein and pectin substances are also present. Vitamins: C, E, carotene; phenolcarboxylic acids (p-coumaric, vanillic); higher aliphatic carbohydrates; organic acids. The main biologically active substances of R. idaeus leaves, which are associated with anti-inflammatory activity, are tannins. The data on pharmacological activity and use of R. idaeus leaves were analyzed. R. idaeus leaves have diaphoretic, antipyretic, anti-inflammatory, immunostimulatory, astringent effect. Medicines based on R. idaeus leaves are used to reinforce immune system, prevent and treat gum inflammation, stomatitis, and digestive disorders. Based on the analysis of literature sources, it is possible to consider the R. idaeus leaves as a promising source for the production of various pharmaceutical substances and the development of drugs with different types of pharmacological activity.
Khishova et al. (Wed,) studied this question.