Coxsackieviruses A6, A10, A16, and A4 emerged as the predominant causes of hand, foot, and mouth disease in China following a marked post-vaccination decline in EV-A71 incidence.
The epidemiology of HFMD in China has shifted post-vaccination, with non-EV-A71 coxsackieviruses becoming predominant, highlighting the need for multivalent vaccines.
Absolute Event Rate: 0% vs 0%
Post-vaccination, EV-A71 incidence declined markedly, while CV-A6, CV-A10, CV-A16, and CV-A4 gradually became predominant, exhibiting distinct geographic and seasonal distributions. These findings underscore the evolving HFMD epidemiology in China and highlight the need for multivalent vaccines and sustained surveillance to effectively control HFMD.
Yu et al. (Sat,) reported a other. Coxsackieviruses A6, A10, A16, and A4 emerged as the predominant causes of hand, foot, and mouth disease in China following a marked post-vaccination decline in EV-A71 incidence.