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Amyloid Imaging and APOE Genotype Disclosure and Short-Term Psychological Distress | Synapse

April 1, 2026Open Access

Amyloid Imaging and APOE Genotype Disclosure and Short-Term Psychological Distress

Key Points

This research aims to examine how amyloid imaging and APOE genotype disclosure influence psychological distress in cognitively unimpaired adults.
Cohort design focusing on cognitively unimpaired adults
Assessment of amyloid imaging and APOE genotype
Evaluation of intrusive thoughts and perceived dementia risk
Associations with intrusive thoughts varied among genetic and biomarker subgroups
Psychological distress linked specifically to biomarker subgroups for perceived dementia risk

Abstract

In this cohort study of cognitively unimpaired adults, associations with intrusive thoughts were observed to differ among genetic and biomarker subgroups; such associations were limited to biomarker subgroups for measures of perceived dementia risk.

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Cite This Study

Grill et al. (Mon,) studied this question.

synapsesocial.com/papers/69ccb68116edfba7beb88290 https://doi.org/https://doi.org/10.1001/jamanetworkopen.2026.3845