RRM2 Promotes the Progression of Intrahepatic Cholangiocarcinoma by Inhibiting Ferroptosis Through the HIF ‐1α Pathway | Synapse
April 1, 2026Open Access
RRM2 Promotes the Progression of Intrahepatic Cholangiocarcinoma by Inhibiting Ferroptosis Through the HIF ‐1α Pathway
Key Points
The aim is to investigate how RRM2 affects ferroptosis and its role in the progression of intrahepatic cholangiocarcinoma (ICC).
Analyzed the relationship between RRM2 and ferroptosis in ICC cells
Investigated the HIF-1α signalling pathway
Used in vitro assays to assess cell progression rates
RRM2 was found to inhibit ferroptosis in ICC cells
Activation of HIF-1α was linked to the effects of RRM2
Targeting the RRM2/HIF-1α axis may offer new therapeutic strategies for ICC
Abstract
RRM2 inhibited ferroptosis by regulating the HIF-1α signalling pathway, thereby promoting the progression of ICC. The RRM2/HIF-1α/ferroptosis axis may become a potential target for ICC therapy.