What question did this study set out to answer?

The study aims to assess the reduction in cardiovascular risk using the triglyceride-glucose index in pancreas transplant recipients.

April 1, 2026Annals of Transplantation0 citationsOpen Access

Reduced Cardiovascular Risk Indicated by Changes in Triglyceride-Glucose Index After Pancreas Transplantation

PSPaweł SkrzypekMedical University of Warsaw MBMałgorzata Buksińska-LisikMedical University of Warsaw PZPaweł ZiemiańskiMedical University of Warsaw

Key Points

The study aims to assess the reduction in cardiovascular risk using the triglyceride-glucose index in pancreas transplant recipients.
Conducted analysis on 86 patients undergoing pancreas transplantation.
Recorded serum triglyceride and glucose levels pre-transplant and at 1, 3, 6, and 12 months post-transplant.
Applied repeated measures ANOVA to evaluate effects over time.
Significant decrease in the mean TyG index observed 1 month post-transplant.
TyG index values showed stable reduction over the 12-month follow-up.
Trend analysis indicated a consistent decline in TyG index from pre-transplant to early and late follow-ups.

Abstract

Background:Pancreas transplantation is the best causal treatment for type I diabetes.The triglyceride-glucose (TyG) index is a validated marker of the long-term risk of cardiovascular episodes.The purpose of this study is to evaluate the potential reduction in cardiovascular risk, using the TyG index as a surrogate marker, in patients undergoing pancreas transplantation. Material/Methods:The analysis was conducted on data obtained from 86 patients undergoing pancreas transplantation at the Department of General and Transplantation Surgery, Medical University of Warsaw.Serum triglyceride and glucose levels were recorded at the stage of qualification for transplantation and at 1, 3, 6, and 12 months after transplantation.The repeated measures ANOVA model was applied to the group of patients with complete data (n=14), showing a statistically significant effect of time.The difference between values before and after 12 months was statistically significant. Results:The mixed model confirmed the significant effect of time on the TyG index value.The mean TyG index value decreased significantly 1 month after transplantation and remained stable.Trend analysis was performed for the TyG index values at 3 time points: before transplant, early follow-up, and late follow-up.The mean TyG index decreased significantly as early as 1 to 3 months. Conclusions:In this cohort of pancreas transplant recipients, transplantation was strongly associated with a reduction in the TyG index, suggesting a lower long-term risk of cardiovascular events.

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