Pulmonary vein isolation significantly reduced median premature ventricular complex burden from 6.82/h at baseline to 3.75/h at 12 months, with diabetes and reduced LVEF predicting high residual burden.
Cohort (n=1,069)
No
Does pulmonary vein isolation reduce premature ventricular complex burden in patients with atrial fibrillation?
Pulmonary vein isolation for atrial fibrillation significantly reduces premature ventricular complex burden, though patients with diabetes or reduced left ventricular ejection fraction remain at higher risk for persistent elevated PVCs.
Absolute Event Rate: 3.75% vs 6.82%
p-value: p=<0.001
PVI significantly reduces PVC burden in most patients, independent of AF recurrence or ablation modality. Diabetes and impaired ventricular function identify patients at risk of persistent high PVC burden. PVI may particularly benefit AF patients with symptomatic PVCs, but larger prospective studies are needed to validate these findings and assess clinical outcomes.
Wörsdörfer et al. (Mon,) conducted a cohort in Atrial fibrillation (n=1,069). Pulmonary vein isolation (PVI) vs. Baseline was evaluated on Median premature ventricular complex (PVC) burden per hour at 12 months (p=<0.001). Pulmonary vein isolation significantly reduced median premature ventricular complex burden from 6.82/h at baseline to 3.75/h at 12 months, with diabetes and reduced LVEF predicting high residual burden.