New dearomatized isoprenylated acylphloroglucinols hyperprzewones A (1) and B (2) were isolated and characterized from the dried aerial parts of Hypericum przewalskii. The structures of these compounds were confirmed by extensive spectroscopic experiments. A facile synthetic route to 1 and 2 was developed via Friedel-Crafts acylation, alkylation, dearomatization, and oxidative 4 + 2 cyclization, giving a 17% overall yield. Moreover, the synthetic derivative 8 exhibited moderate inhibition on T-type calcium channels Cav3.2.
Li et al. (Wed,) studied this question.