Radio-dynamic Therapy with 5-Aminolevulinic Acid for Malignant Glioma: Alterations in the Expression of Immune- and Angiogenesis-Related Factors

Key Points

• This research examines the therapeutic effects and mechanisms of radio-dynamic therapy using 5-aminolevulinic acid on malignant glioma.
• Evaluated RDT effects on malignant glioma cell lines under normal and hypoxic conditions.
• Measured the production of reactive oxygen species and cell death rates.
• Assessed the expression levels of HIF-1α, VEGF, and PD-L1.
• RDT enhanced reactive oxygen species production and cell death in normal oxygen environments.
• Effects of RDT were reduced under low oxygen conditions.
• RDT suppressed expression of hypoxia-related factors (HIF-1α, VEGF) and modulated immune response factors (PD-L1).