Structural remodeling and diastolic dysfunction are prevalent in HFpEF and independently predict increased morbidity and mortality, supporting their use in diagnostic and prognostic criteria.
Left ventricular hypertrophy or concentric remodeling, LA enlargement, and diastolic dysfunction were present in the majority of patients with HFPEF. Left ventricular mass and LA size were independently associated with an increased risk of morbidity and mortality. The presence of structural remodeling and diastolic dysfunction may be useful additions to diagnostic criteria and provide important prognostic insights in patients with HFPEF.
Zile et al. (Tue,) studied this question.
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