VD3 deficiency triggers divergent, tissue-specific regulatory responses, suggesting that the brain may preserve a more stable internal environment than osseous tissue. These findings reflect a degree of cerebral metabolic regulation distinct from the systemic endocrine susceptibility driven by the FGF23 axis. However, the functional significance of these localized patterns and their underlying neuroprotective implications requires further comprehensive and robust experimental validation.
Shymanskyi et al. (Sun,) studied this question.