Investigating the Role of TNFSF12 in Thyroid Cancer Progression via Single‐Cell RNA Sequencing and Integrated Multiomics Analyses | Synapse
April 5, 2026Open Access
Investigating the Role of TNFSF12 in Thyroid Cancer Progression via Single‐Cell RNA Sequencing and Integrated Multiomics Analyses
Key Points
The aim is to examine how TNFSF12 influences thyroid cancer progression through comprehensive analyses.
Utilized single-cell RNA sequencing to identify cellular dynamics in thyroid cancer.
Conducted integrated multiomics analyses to explore the regulatory networks.
Analyzed the expression patterns of TNFSF12 in different contexts.
Identified a myeloid-centered regulatory network involved in thyroid cancer.
Demonstrated TNFSF12 acts as a context-dependent oncogene.
Provided insights for potential targeted therapy and immunotherapeutic strategies.
Abstract
Our study reveals a myeloid-centered regulatory network in thyroid cancer and highlights TNFSF12 as a context-dependent oncogene, offering novel insights into targeted therapy and immunotherapeutic strategies.