Abstract Background: Z-DNA binding protein 1 (ZBP1) is an interferons (IFN)-stimulated cytosolic sensor of Z-nucleic acids (Z-NA) that regulates PANoptosis (pyroptosis, apoptosis, and/or necroptosis) and thereby drives potent anti-tumor immune responses. However, the mechanisms controlling ZBP1 protein stability in tumors—and whether they can be therapeutically manipulated to induce ICD—remain unclear. We sought to define regulatory pathways that govern ZBP1 abundance in ovarian cancer and to test strategies that exploit ZBP1 activation for antitumor therapy. Methods Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 7462.
Liao et al. (Fri,) studied this question.