Primary Aldosteronism, a New Clinical Entity

Article1 January 1956PRIMARY ALDOSTERONISM, A NEW CLINICAL ENTITYJEROME W. CONN, M.D., F.A.C.P., LAWRENCE H. LOUIS, SCD.JEROME W. CONN, M.D., F.A.C.P., LAWRENCE H. LOUIS, SCD.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAldosterone, the newly discovered normal adrenal secretory product,1-6has attracted the attention of a great many clinical investigators because of its apparent rôle in the pathogenesis of a number of clinical disorders. This extremely potent sodium-retaining corticoid has been found to be present in excessive amounts in the urine of edematous nephrotics,7, 8cardiacs with congestive failure,9, 10patients with decompensated hepatic cirrhosis11-13and women with eclampsia.14-16All of these conditions manifest marked edema, but it is obvious that theprimarydifficulty in each condition isnotdue to increased activity of a sodium-retaining steroid. It seems reasonable to assume...Bibliography1. SimpsonTaitWettsteinNeherVon EuwReichstein SAJFARJT: Isolierung eines neuen kristallisierten Hormons aus Nebennieren mit besonders hoher Wirksamkeit auf den Mineralstoffwechsel, Experientia 9: 333, 1953. CrossrefMedlineGoogle Scholar2. SimpsonTaitWettsteinNeherVon EuwSchindlerReichstein SAJFARJOT: Konstitution des Aldosterons, des neuen Mineralocorticoid, Experientia 10: 132, 1954. CrossrefMedlineGoogle Scholar3. SimpsonTaitWettsteinNeherVon EuwSchindlerReichstein SAJFARJOT: Aldosteron, Isolierung und Eigenschaften. 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ConnLouis JWLH: Production of endogenous salt-active corticoids as reflected in the concentrations of sodium and chloride of thermal sweat, J. Clin. Endocrinol. 10: 12, 1950. CrossrefGoogle Scholar34. SimpsonTait SAJF: Some recent advances in methods of isolation and the physiology and chemistry of electrocortin, Recent Progress in Hormone Research, in press. Google Scholar35. Schwartz WB: Potassium and the kidney, in press. Google Scholar36. EvansMilne BMMD: Potassium-losing nephritis presenting as a case of periodic paralysis, Brit. M. J. 2: 1067, 1954. CrossrefMedlineGoogle Scholar37. CopeGardcia-Llaurado CLJ: The occurrence of electrocortin in human urine, Brit. M. J. 1: 1290, 1954. CrossrefMedlineGoogle Scholar38. WyngaardenKeitelIsselbacker JBHGJ: Potassium depletion and alkalosis. Their association with hypertension and renal insufficiency, New England J. Med. 250: 597, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JEROME W. CONN, M.D., F.A.C.P.; LAWRENCE H. LOUIS, SCD.Affiliations: Ann Arbor, Michigan*Presented at the Thirty-sixth Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April 27, 1955.From the Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.†This study has been supported in part by a grant from the Research and Development Board, Office of the Surgeon General, U. S. Army. 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CHARLES MCMILLAN, M.D.Present Concepts Regarding Management of HypertensionMineralocorticoid action of adrenocortical hormonesTHE ALDOSTERONE BLOCKING EFFECTS OF SPIROLACTONESPrimary AldosterokismTHE VIRILIZING SYNDROMESAdrenal insufficiency in postmature Holstein calvesThe Role of Surgery in the Modern Treatment of HypertensionEssential Hypertension and AldosteroneIdiopathic EdemaHypertension associated with regenerating adrenal cortical tissue in the ratCURRENT CONCEPTS OF THE MECHANISMS OF HYPERTENSIONThe syndrome of mineralocorticoid excess: Primary aldosteronismTHE SWEAT GLANDSPrimary hyperaldosteronism without adrenal tumorManagement of functioning tumors of the adrenal cortexPortal HypertensionThe consequences of potassium depletionPrimary aldosteronismPathophysiologie der HerzinsuffizienzDrüsen mit innerer SekretionSpezielle pathologische AnatomieDrüsen mit innerer SekretionDrüsen mit innerer SekretionTransmembrane gationic gradient and blood pressure regulationEvaluation and Treatment of the Patient with an Elevated Blood PressureABNORMAL RESPONSE OF ŒDEMATOUS PATIENTS TO ALDOSTERONE OR DEOXYCORTONEChronische Hyperosmolarit�t bei Hirnsch�den an Hand eines Falles von CyklopenventrikelTUMOURS OF THE RENAL PELVIS: REVIEW OF SIXTY-FOUR CASESHYPOKALAEMIC PARESES AFTER BILATERAL URETEROSIGMOIDOSTOMY, and TREATMENT OF A CASEEndocrine factorsThe alkali metal ions in the organismStörungen des Elektrolyt- und Wasserhaushaltes bei HerzinsuffizienzAldosteron, Glomerulusfiltrat und NatriumretentionAldosteroneRecent studies on pathophysiologic mechanisms in human neoplastic diseaseTHE SYNDROME OF MINERALOCORTICOID EXCESSThe kidney in potassium depletionAldosterone in Experimental and Clinical MedicineA CASE OF CUSHING'S SYNDROME WITH PIGMENTATION AND SEVERE HYPOKALAEMIC ALKALOSISThe Management of the Hypertensive PatientAscites in Liver Disease: Pathogenesis and TreatmentThe pathogenesis of essential hypertensionDie tubulären NierensyndromePRIMARY ALDOSTERONISM: A BRIEF ACCOUNT 1DwarfismHypoaldosteronismPotassium deficiency of renal and adrenal originCurrent Diagnosis of Systemic Arterial HypertensionAldosteronausscheidung und tubul�re NierenfunktionEmergencies Related to Acute and Chronic Renal FailureCase 43051Primary AldosteronismObservations on Primary AldosteronismUnilateral Nephrectomy in Hypertensive DiseaseEXPERIMENTAL PRODUCTION OF MORPHOLOGICAL CHANGES RESEMBLING CONN'S SYNDROMEMALIGNANT HYPERTENSION WITH INCREASED SECRETION OF ALDOSTERONE AND DEPLETION OF POTASSIUMNebennierenrinde und Wasser-Salzstoffwechsel unter besonderer Ber�cksichtigung von AldosteronADRENOCORTICAL TUMOUR WITH HYPOKALÆMIA AND FLACCID MUSCLE PARALYSISPRIMARY ALDOSTERONISMTHROMBOSIS OF THE SIGMOID SINUSDiagnosis & management of renal failurePrimary Aldosteronism 1 January 1956Volume 44, Issue 1 Page: 1-15 Keywords Adenomas Cardiac ablation Edema Endocrinology Nephritis Pathogenesis Proteinuria Research grants Surgeons Urine ePublished: 1 December 2008 Issue Published: 1 January 1956 Copyright & PermissionsCopyright ©, 1956, by The American College of PhysiciansPDF downloadLoading ...