Does aortic valve replacement improve myocardial remodeling and fibrosis in patients with aortic stenosis?
Following aortic valve replacement, diffuse myocardial fibrosis and cellular hypertrophy regress, demonstrating that human diffuse fibrosis is plastic and measurable by CMR.
Post-AVR, focal fibrosis does not resolve, but diffuse fibrosis and myocardial cellular hypertrophy regress. Regression is accompanied by structural and functional improvements suggesting that human diffuse fibrosis is plastic, measurable by CMR and a potential therapeutic target. (Regression of Myocardial Fibrosis After Aortic Valve Replacement; NCT02174471).
Treibel et al. (2018) studied this question.