Associations between Self-reported Symptoms, Quality of Life, and Work Productivity Loss among Japanese Workers: A Cross-sectional Analysis of a Large-scale Questionnaire-based Person-reported Outcomes Database (PRO-DB) | Synapse
April 8, 2026Open Access
Associations between Self-reported Symptoms, Quality of Life, and Work Productivity Loss among Japanese Workers: A Cross-sectional Analysis of a Large-scale Questionnaire-based Person-reported Outcomes Database (PRO-DB)
Key Points
To explore the relationships between self-reported symptoms, quality of life, and work productivity loss among Japanese workers.
Conducted a cross-sectional analysis using a large-scale questionnaire-based database.
Analyzed associations between symptom severity and work productivity loss.
Evaluated the quality of life impacts of reported symptoms.
Identified a significant dual burden of both mild and severe symptoms among workers.
Found that worsening symptoms correlate with decreased work productivity and quality of life.
Suggest that targeted interventions could improve overall well-being.
Abstract
These findings highlight a dual burden of symptoms among Japanese workers. Effective interventions should address both rare severe symptoms and common mild symptoms to improve well-being and productivity.