Is elevated WBC count associated with reduced epicardial blood flow, worse myocardial perfusion, and poorer clinical outcomes in patients with acute myocardial infarction?
Elevated WBC count in the setting of AMI is associated with impaired myocardial perfusion, increased thrombus burden, and higher rates of heart failure and mortality, supporting the link between inflammation and adverse cardiovascular outcomes.
Elevation in WBC count was associated with reduced epicardial blood flow and myocardial perfusion, thromboresistance (arteries open later and have a greater thrombus burden), and a higher incidence of new congestive heart failure and death. These observations provide a potential explanation for the higher mortality rate observed among AMI patients with elevated WBC counts and helps explain the growing body of literature that links inflammation and cardiovascular disease.
Barron et al. (Tue,) studied this question.
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