March 24, 2003

Family History and Cardiovascular Risk in Familial Hypercholesterolemia

Structured PICO

Does the measurement of LDL-C, lipoprotein(a), and HDL-C levels in children from FH families allow accurate diagnosis and identification of highest CVD risk kindreds?

Population

Children in familial hypercholesterolemia (FH) families/kindreds

Intervention

Measurement of LDL-C, lipoprotein(a), and HDL-C levels

Outcome

Diagnosis of FH and identification of highest cardiovascular disease (CVD) risk kindredssurrogate

Lipid profiling in children from FH families is crucial for early diagnosis and identifying kindreds at the highest cardiovascular risk.

Abstract

In FH families, LDL-C levels allow accurate diagnosis of FH in childhood. Moreover, increased LDL-C and lipoprotein(a) and decreased HDL-C levels in children identify FH kindreds with the highest CVD risk.

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Cite This Study

Wiegman et al. (Mon,) studied this question.

synapsesocial.com/papers/69d73a2eef4aa71f97f308ec https://doi.org/https://doi.org/10.1161/01.cir.0000058166.99182.54

Discussion

Journals

Circulation

Institutions

Erasmus University Rotterdam

Erasmus MC

References and Citations

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