February 23, 2019Open Access

Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling

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Abstract

Our work shows that oxidized ATM-mediated glycolysis enhancement in hypoxic stromal fibroblasts plays an essential role in cancer cell invasion and metastasis and may implicate oxidized ATM as a target for breast tumor treatment. FUND: This research was supported by National Natural Science Foundation of China.

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Sun et al. (Sat,) studied this question.

synapsesocial.com/papers/69d7bfbf3b601d7be3ae2aa5 https://doi.org/https://doi.org/10.1016/j.ebiom.2019.02.025

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