March 18, 2009Open Access
The LDL Receptor
Key Points
Key points are not available for this paper at this time.
Abstract
In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.
Connected Papers
Building similarity graph...
Analyzing shared references across papers
Discussion
Loading...
Authors
Joseph L. Goldstein
The University of Texas Southwestern Medical Center
M
Michael S. Brown
Marquette University
Journals
Arteriosclerosis Thrombosis and Vascular Biology
Actions
Institutions
The University of Texas Southwestern Medical Center
References and Citations
Connected Papers
Building similarity graph...
Analyzing shared references across papers
Discussion
Loading...