June 6, 2017

Surfactant Proteins-A and -D Attenuate LPS-Induced Apoptosis in Primary Intestinal Epithelial Cells (IECs)

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Abstract

SP-A and SP-D attenuate LPS-induced increases in apoptosis, caspase-3, and BAX/Bcl-2 in IECs. Attenuation of LPS-induced activation of TLR4 and P38 MAPK signaling pathways represents potential mechanisms for the protective effects of SP-A/D on apoptosis.

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Zhang et al. (Tue,) studied this question.

synapsesocial.com/papers/69d8396e8c03fbaff8bee334 https://doi.org/https://doi.org/10.1097/shk.0000000000000919

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5SHP-1–Pyk2–Src Protein Complex and p38 MAPK Pathways Independently Regulate IL-10 Production in Lipopolysaccharide-Stimulated Macrophages2013 · 28 citations

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