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Explore the challenges of diagnosing dual pathology in atypical intracranial lesions stemming from glioblastoma and adenocarcinoma.

April 10, 2026Open Access

Basal ganglia glioblastoma with lung adenocarcinoma tumor-to-tumor metastasis and atypical early imaging presentation: illustrative case

Key Points

Explore the challenges of diagnosing dual pathology in atypical intracranial lesions stemming from glioblastoma and adenocarcinoma.
Illustrative case examination of a patient with atypical symptoms.
Integration of imaging techniques to assess early glioblastoma features.
Histopathological and molecular profiling for accurate diagnosis.
Identification of glioblastoma presenting with nonenhancing imaging characteristics.
Recognition of potential for tumor-to-tumor metastasis.
Emphasis on the importance of comprehensive diagnostic approaches.

Abstract

This case highlights the importance of maintaining diagnostic suspicion for dual pathology in atypical intracranial lesions with progressive, otherwise unexplained symptoms. Furthermore, this case highlights the challenges in recognizing early glioblastoma presenting with nonenhancing, diffusion-restricting imaging features that may closely mimic subacute ischemic stroke. The integration of histopathology, immunochemistry, and molecular profiling is critical in recognizing this entity and carries significant implications for accurate diagnosis and treatment. https://thejns.org/doi/10.3171/CASE25992.

Basal ganglia glioblastoma with lung adenocarcinoma tumor-to-tumor metastasis and atypical early imaging presentation: illustrative case

Key Points

Abstract

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