Comparative Detection Performance of PSMA and Non-PSMA PET Tracers in Recurrent and Primary Prostate Cancer: A Systematic Review and Network Meta-Analysis.

Key Points

• The aim is to evaluate the effectiveness of PSMA versus non-PSMA PET tracers in detecting prostate cancer.
• Conducted a systematic review of existing literature.
• Performed a network meta-analysis to compare detection rates.
• Analyzed performance metrics for various PSMA and non-PSMA tracers.
• PSMA tracers show superior detection rates for biochemical recurrence.
• Among PSMA tracers, 18F-labeled agents consistently outperform 68Ga-PSMA-11.
• Recommendation favors the use of 18F-labeled PSMA tracers whenever available.