Myonuclear Domain‐Associated and Central Nucleation‐Dependent Spatial Restriction of Dystrophin Protein Expression

Key Points

• This research aims to understand how dystrophin is localized within muscle cells and the implications for therapy.
• Investigated dystrophin expression in myofibers
• Analyzed central nucleation impact on dystrophin localization
• Evaluated barriers to dystrophin restoration
• Identified spatial restrictions in dystrophin expression within myofibers
• Revealed significant challenges to therapeutic restoration in centrally nucleated fibers
• Demonstrated the importance of myonuclear domain in effective muscle repair