Mitoxantrone was identified as a translation inhibitor targeting the bacterial ribosome with an IC50 of 14.10 mM, demonstrating a bacteriostatic effect comparable to Clindamycin.
A computational pipeline and in vitro validation successfully identified several small molecules, including Mitoxantrone, as inhibitors of bacterial protein synthesis.
A hierarchical VS pipeline to target the bacterial ribosome PTC and in vitro translation assays identified Mitoxantrone as a potent inhibitor of E. coli protein synthesis, and Plerixafor, Olcegepant, and Ziritaxestat as lead compounds.
Yuce et al. (2026) studied Bacterial infection (in vitro). Mitoxantrone vs. Clindamycin was evaluated on IC50 for translation inhibition. Mitoxantrone was identified as a translation inhibitor targeting the bacterial ribosome with an IC50 of 14.10 mM, demonstrating a bacteriostatic effect comparable to Clindamycin.
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