Most typhoon-exposed individuals with PTSD may exhibit structural alterations in brain white matter. By combining fixel-based analysis (FBA) with machine learning, this study identified diffusion markers within specific white matter tracts and demonstrated their potential diagnostic value for distinguishing PTSD from trauma-exposed controls. These findings enhance our understanding of microstructural white matter changes and their spatial distribution in PTSD and also suggest potential imaging biomarkers for its diagnosis.
Zhang et al. (Wed,) studied this question.