What question did this study set out to answer?

This research investigates the outcomes of left atrial appendage occlusion in patients with heart failure with reduced ejection fraction.

April 10, 2026Open Access

Outcomes of Left Atrial Appendage Occlusion in Heart Failure With Reduced Ejection Fraction

Key Result

Heart failure with reduced ejection fraction affects one in nine LAAO patients and is associated with higher risks of major in-hospital complications and readmission.

Key Points

This research investigates the outcomes of left atrial appendage occlusion in patients with heart failure with reduced ejection fraction.
Analyzed data from patients treated with left atrial appendage occlusion (LAAO)
Identified incidence of complications and hospital readmissions relative to heart failure status
One out of nine patients undergoing LAAO has heart failure with reduced ejection fraction (HFrEF)
HFrEF patients face a higher risk of major in-hospital complications
Increased readmission rates observed in HFrEF patients post-LAAO

Structured PICO

Does the presence of HFrEF increase the risk of major in-hospital complications and hospital readmission in patients undergoing LAAO?

Population

Patients treated with Left Atrial Appendage Occlusion (LAAO) in the United States

Intervention

Left Atrial Appendage Occlusion (LAAO) in patients with Heart Failure with Reduced Ejection Fraction (HFrEF)

Outcome

Major in-hospital complications and hospital readmissionhard clinical

HFrEF is a significant risk factor for in-hospital complications and readmissions in patients undergoing LAAO.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

One out of nine patients treated with LAAO in the United States has HFrEF, which is associated with a higher risk of major in-hospital complications and hospital readmission.