Biologics for chronic rhinosinusitis with nasal polyps: from downstream cytokine blockade to upstream epithelial targets

Key Points

• The research aims to explore the effectiveness of biologic therapies in managing chronic rhinosinusitis with nasal polyps.
• Review of existing literature on biologic treatments for chronic rhinosinusitis with nasal polyps.
• Analysis of upstream and downstream treatment strategies.
• Discussion of future biomarker-guided therapeutic approaches.
• Biologic therapy improves management strategies for chronic rhinosinusitis with nasal polyps.
• Upstream-targeted treatments show promise for patients with refractory or mixed symptoms.
• Future research directions include a greater focus on biomarkers and long-term outcomes.