What question did this study set out to answer?

This research aims to explore how NR3C1 influences IRGM1 in regulating inflammation and pyroptosis after subarachnoid hemorrhage.

April 10, 2026

Regulation of IRGM1-Mediated Pyroptosis and Neuroinflammation by Transcription Factor NR3C1 Alleviates Early Brain Injury After Subarachnoid Hemorrhage

Key Result

NR3C1 activation of IRGM1 alleviates early brain injury after subarachnoid hemorrhage by inhibiting inflammation, pyroptosis, and oxidative stress.

Key Points

This research aims to explore how NR3C1 influences IRGM1 in regulating inflammation and pyroptosis after subarachnoid hemorrhage.
Activated NR3C1 to study its transcriptional effects on IRGM1.
Assessed levels of inflammation and oxidative stress in brain tissues post-SAH.
Evaluated neuronal damage to measure early brain injury outcomes.
NR3C1 activation significantly reduced neuroinflammation and pyroptosis.
Oxidative stress levels were markedly lower in the presence of active NR3C1.
Early brain injury outcomes improved following modulation of the NR3C1/IRGM1 axis.

Structured PICO

Does targeting the NR3C1/IRGM1 axis alleviate early brain injury after subarachnoid hemorrhage?

Population

Models of early brain injury after subarachnoid hemorrhage (SAH)

Intervention

Targeting the NR3C1/IRGM1 axis (NR3C1 transcriptional activation of IRGM1)

Outcome

Inflammation, pyroptosis, oxidative stress, and early brain injury (EBI)surrogate

Activation of the NR3C1/IRGM1 axis reduces inflammation and pyroptosis, offering a potential therapeutic target for early brain injury following subarachnoid hemorrhage.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

NR3C1 transcriptionally activated IRGM1 to inhibit inflammation, pyroptosis, and oxidative stress, thereby alleviating EBI after SAH, and targeting the NR3C1/IRGM1 axis might provide a novel therapeutic strategy for SAH.

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Cite This Study

Xin et al. (Fri,) reported a other. NR3C1 activation of IRGM1 alleviates early brain injury after subarachnoid hemorrhage by inhibiting inflammation, pyroptosis, and oxidative stress.

synapsesocial.com/papers/69d896676c1944d70ce07e01 https://doi.org/https://doi.org/10.1097/shk.0000000000002846

Discussion

Journals

Shock

Institutions

First People’s Hospital of Zunyi

References and Citations

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