July 15, 2016Open Access

LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro

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Abstract

Our findings show that patients with type 2 diabetes mellitus are characterised by increased plasma LIGHT levels. Our in vitro findings suggest that LIGHT may contribute to the progression of type 2 diabetes mellitus by attenuating insulin secretion in pancreatic islet cells and by contributing to vascular inflammation.

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Halvorsen et al. (Fri,) studied this question.

synapsesocial.com/papers/69d937b1da3af5b1d0836096 https://doi.org/https://doi.org/10.1007/s00125-016-4036-y

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