Does the dose-response association between moderate to vigorous physical activity and incident morbidity and mortality differ by cardiovascular health status?
For individuals with cardiovascular disease, higher volumes of moderate to vigorous physical activity continue to reduce risk linearly, whereas benefits plateau for healthy individuals and those with risk factors.
MVPA is beneficial for reducing adverse outcomes, but the shape of the association depends on cardiovascular health status. A curvilinear association was found in healthy and CVRF individuals with a steep risk reduction at low to moderate MVPA volumes and benefits plateauing at high(er) MVPA volumes. CVD patients demonstrated a linear association, suggesting a constant reduction of risk with higher volumes of MVPA. Therefore, individuals with CVDs should be encouraged that "more is better" regarding MVPA. These findings may help to optimize exercise prescription to gain maximal benefits of a physically active lifestyle.
Bakker et al. (Thu,) studied this question.
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