May 24, 2012Open Access

Merging Visible-Light Photocatalysis and Transition-Metal Catalysis in the Copper-Catalyzed Trifluoromethylation of Boronic Acids with CF3I

Key Points

Key points are not available for this paper at this time.

Abstract

This communication describes the development of a mild method for the cross-coupling of arylboronic acids with CF(3)I via the merger of photoredox and Cu catalysis. This method has been applied to the trifluoromethylation of electronically diverse aromatic and heteroaromatic substrates and tolerates many common functional groups.

Read Full Paperexternally

Perguntar à IA

Bookmark

View Full Paper

Cite This Study

Ye et al. (Thu,) studied this question.

synapsesocial.com/papers/69dac00f78a3e0e28868441e https://doi.org/https://doi.org/10.1021/ja301553c

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkynes and Aryl Boronic Acids Using (Trifluoromethyl)trimethylsilane2012 · 165 citations
2A General Strategy for the Perfluoroalkylation of Arenes and Arylbromides by Using Arylboronate Esters and [(phen)CuR<sup>F</sup>]2011 · 251 citations
3Experimental and Theoretical Studies on Radical Trifluoromethylation of Titanium Ate and Lithium Enolates2006 · 58 citations
4Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments2008 · 1,141 citations
5Mechanistic and Computational Studies of Oxidatively-Induced Aryl−CF<sub>3</sub> Bond-Formation at Pd: Rational Design of Room Temperature Aryl Trifluoromethylation2011 · 198 citations

Perguntar à IA

Bookmark

View Full Paper