Background Autologous dentin has emerged as a biologically active alternative to xenogeneic grafts, yet its clinical application in periodontal healing remains limited. Leukocyte- and platelet-rich fibrin (L-PRF) provides a scaffold that releases biomolecules to enhance wound healing. This case series evaluates the clinical and radiographic outcomes of a fully autologous L-PRF dentin block for the treatment of infrabony periodontal defects. Methods Six patients presenting with twenty infrabony defects were treated with an L-PRF dentin block graft composed of particulate autologous dentin combined with L-PRF membranes and liquid fibrinogen. At baseline and after 6 months, Clinical attachment level (CAL), probing depth (PD), and bleeding on probing (BOP) were evaluated clinically, and defect dimensions were assessed by Cone-beam computed tomography (CBCT). Pain was evaluated using a visual analog scale at 0, 7, 14, and 21 days. Results Significant improvements were observed in all clinical parameters at 6 months: CAL decreased from 5.7 mm (95% CI: 5.1–6.2) to 1.6 mm (95% CI: 0.8–2.4; p 0.0001), PD decreased from 7.2 mm (95% CI: 6.2–8.2) to 3.7 mm (95% CI: 3.0–4.3; p 0.0001), and BOP from 80% to 10% ( p 0.0001). CBCT analyses demonstrated significant reductions in defect depth ( p 0.03) and mesiodistal and buccopalatal dimensions ( p 0.0001). Patients reported low postoperative pain from day 7 onward. Conclusion The L-PRF dentin block represents a promising, fully autologous, biologically based approach for the treatment of infrabony periodontal defects, associated with favorable preliminary clinical and radiographic outcomes with minimal postoperative discomfort. These findings suggest that this approach may represent a feasible and biologically compatible alternative to conventional graft materials. However, randomized clinical trials are needed to confirm these preliminary findings.
Anwandter-Beckhaus et al. (Wed,) studied this question.