What question did this study set out to answer?

To evaluate the feasibility of whole-brain volume loss as a marker for delayed secondary ischaemic injury.

April 12, 2026

MRI measurement of the delayed secondary ischaemic injury following endovascular thrombectomy: results from the REPERFUSE-NA1 study.

Key Points

To evaluate the feasibility of whole-brain volume loss as a marker for delayed secondary ischaemic injury.
Conducted MRI assessments of brain volume following endovascular thrombectomy.
Measured changes in whole-brain volume to assess ischaemic injury.
Applied MR-based markers to evaluate the implications for neuroprotectant trials.
Whole-brain volume loss was established as a viable measurement method.
Findings align with previous studies on ischaemic injury markers.
Suggests that MR-based methods can enhance future clinical trials for neuroprotectants.

Abstract

This study indicates that whole-brain volume loss is a feasible measurement of delayed secondary ischaemic injury. Future neuroprotectant clinical trials could utilise MR-based markers of delayed ischaemic injury.

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