Quantification and pharmacokinetic assessment of SB225002 in mouse: a selective non-peptide CXCR2 antagonist

Key Points

• The aim is to develop a method to quantify SB225002 and assess its pharmacokinetic properties in mice.
• Developed a UHPLC-MS/MS method for quantification
• Validated the method using mouse plasma
• Analyzed pharmacokinetic parameters of SB225002
• Successfully determined SB225002 levels in mouse plasma
• Reported pharmacokinetic parameters for SB225002 for the first time