Persistent hyperCKemia and male sex strongly predicted underlying primary neuromuscular disease in pediatric patients, with odds ratios of 8.5 and 5.1, respectively.
Cohort (n=119)
No
What are the clinical predictors of underlying neuromuscular disease and metabolic myopathy in pediatric patients with hyperCKemia?
In pediatric patients with hyperCKemia, male sex, persistent hyperCKemia, and CK levels >1000 UI/L are strong predictors of an underlying neuromuscular or metabolic disorder.
Effect estimate: OR 8.524 (95% CI 3.145-23.106)
p-value: p=<0.001
• Persistent hyperCKemia and male sex were identified as independent predictors of primary disease. • Most primary disorders occurred in patients with CK over 1000 UI/L, and higher inter-crisis CK levels were associated with an increased likelihood of underlying disease.
Martins et al. (Fri,) conducted a cohort in Pediatric hyperCKemia (n=119). Persistent hyperCKemia vs. Non-persistent hyperCKemia was evaluated on Diagnosis of primary neuromuscular disease or metabolic myopathy (OR 8.524, 95% CI 3.145-23.106, p=<0.001). Persistent hyperCKemia and male sex strongly predicted underlying primary neuromuscular disease in pediatric patients, with odds ratios of 8.5 and 5.1, respectively.