Monogenic PD in Africa shows allelic and locus heterogeneity with a very strong contribution of the LRRK2 p.(Gly2019Ser) founder variant in NA. Notably, in more than 98% of SSA PD patients no molecular cause was found. Next-generation sequencing-based technology could uncover novel causative variants that may be specific to these populations. © 2026 International Parkinson and Movement Disorder Society.
Banjaw et al. (Thu,) studied this question.
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