November 6, 2020

Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure

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Abstract

This study demonstrates that circulating monocytes and T cells of patients with HF harboring clonal hematopoiesis-driver mutations in DNMT3A exhibit a highly inflamed transcriptome, which may contribute to the aggravation of chronic HF.

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Abplanalp et al. (Fri,) studied this question.

synapsesocial.com/papers/69dc5e20d74bf23813c0fefb https://doi.org/https://doi.org/10.1161/circresaha.120.317104

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