Human recombinant IL-1 alters the electrical properties of ventricular cells by modifying calcium channel conductance through lipid second messenger pathways.
IL-1 modifies electrical properties of cardiac cells via lipid second messengers generated by cyclo-oxygenase and lipoxygenase pathways. Voltage clamp analyses suggest that these effects are mediated, at least in part, by changes in the conductance of calcium channels.
Li et al. (Mon,) studied this question.