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Catalytic containers: A supramolecular metal–ligand assembly M4L6 is utilized as a catalytic host for the unimolecular carbon–carbon bond-forming rearrangement of enammonium cations (see scheme). The restricted reaction space of the supramolecular structure forces the substrate to adopt a reactive conformation upon binding to the interior. The assembly achieves up to 850-fold rate acceleration of the rearrangement.
Fiedler et al. (Fri,) studied this question.