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Hip fracture is a severe adverse effect with TZDs, affecting both sexes; labels should be changed to warn of this. The excess mortality is at least as much as expected from the reported association of pioglitazone with bladder cancer.
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Helen M. Colhoun
Preventive Cardiology
Shona Livingstone
University of Dundee
Helen C. Looker
National Institute of Diabetes and Digestive and Kidney Diseases
Diabetologia
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)
University of Edinburgh
University of Glasgow
University of Dundee
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Colhoun et al. (Mon,) studied this question.
synapsesocial.com/papers/69dd460d656f15f1fc100f8d — DOI: https://doi.org/10.1007/s00125-012-2668-0