Does endogenous Thrombospondin-1 prevent expansion of healing myocardial infarcts?
Endogenous TSP-1 plays a critical role in limiting infarct expansion and preventing fibrotic remodeling after myocardial infarction.
The infarct border zone may be capable of modulating the healing process through its unique extracellular matrix content. The selective endogenous expression of TSP-1 in the infarct border zone may serve as a "barrier," limiting expansion of granulation tissue and protecting the noninfarcted myocardium from fibrotic remodeling.
Frangogiannis et al. (Wed,) studied this question.