What question did this study set out to answer?

This research aims to identify factors that predict recurrence in HPV-associated oropharyngeal squamous cell carcinoma.

April 16, 2026

Predictors of Recurrence in Human Papillomavirus‐Associated Oropharyngeal Squamous Cell Carcinoma

Key Points

This research aims to identify factors that predict recurrence in HPV-associated oropharyngeal squamous cell carcinoma.
Analyzed recurrence and survival patterns in patients with HPV+ OPSCC
Assessed the role of perineural invasion in recurrence
Examined individual surveillance approaches based on patient characteristics
Distinct patterns of recurrence and survival were observed in HPV+ OPSCC patients
Perineural invasion was identified as a significant predictor of recurrence
Current findings support the need for more personalized surveillance strategies for these patients

Abstract

Our results highlight distinct patterns of recurrence and survival which support the consideration of more individualized surveillance approaches, especially in HPV+ OPSCC patients with perineural invasion.

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