Mucinous histology and resistance to immune checkpoint blockade in patients with microsatellite instability-high metastatic colorectal cancer | Synapse
April 16, 2026The Oncologist1 citationsOpen Access
Examine the link between mucinous histology and resistance to immune checkpoint inhibitors in microsatellite instability-high metastatic colorectal cancer.
Analyzed patient data with mucinous histology and microsatellite instability-high status.
Evaluated response to immune checkpoint inhibitors.
Assessed associations with clinical outcomes using statistical analysis.
Mucinous histology is linked to increased resistance to immune checkpoint inhibitors.
Patients with dMMR/MSI-H mCRC exhibit distinct challenges in treatment.
Management strategies may need adjustment based on histological findings.
Abstract
Mucinous histology is associated with ICIs resistance, particularly AR, in dMMR/MSI-H mCRC. These findings may be useful to guide the management of this disease in practice.