Women undergoing atrial fibrillation catheter ablation had a significantly higher long-term recurrence risk compared to men (adjusted HR 1.24; 95% CI 1.06-1.45; P=0.009).
Cohort (n=4,202)
Yes
Does female sex impact ablation strategies and clinical outcomes in patients undergoing catheter ablation for atrial fibrillation?
In real-world practice, women undergoing AF ablation receive more complex substrate modification but face a higher long-term risk of arrhythmia recurrence compared to men.
Effect estimate: adjusted HR 1.24 (95% CI 1.06-1.45)
p-value: p=0.009
AbstractBackground Sex differences in atrial fibrillation (AF) ablation strategies and outcomes remain insufficiently characterized. Objective To evaluate the impact of sex on ablation strategies and clinical outcomes in patients with paroxysmal (PAF) and persistent AF (PsAF) in real-world settings. Methods Data from the REAL-AF Registry were analyzed (January 2018-May 2023). Demographics, intraoperative parameters, and outcomes were compared by sex, stratified by AF type. Results A total of 4,202 patients (41.1% women) were included. Women were older (69.02 ± 9.18 vs. 65.32 ± 10.49 years), had higher CHA2DS2-VASc scores (3.36±1.43 vs. 2.33±1.45), and were more frequently diagnosed with PAF (72.8% vs. 61.3%) (pConclusions Women face higher long-term arrhythmia recurrence risks, especially in ablation strategies involving SM, despite comparable acute and short-term outcomes.
Zhang et al. (Wed,) conducted a cohort in Paroxysmal and persistent atrial fibrillation (n=4,202). Female sex vs. Male sex was evaluated on Long-term recurrence (adjusted HR 1.24, 95% CI 1.06-1.45, p=0.009). Women undergoing atrial fibrillation catheter ablation had a significantly higher long-term recurrence risk compared to men (adjusted HR 1.24; 95% CI 1.06-1.45; P=0.009).