What question did this study set out to answer?

The aim is to develop an efficient and environmentally friendly method for synthesizing 2-amino-4H-chromenes using itaconic acid.

April 17, 2026

Environmentally Benign Organocatalysis: Itaconic Acid‐Mediated Synthesis of 2‐Amino‐4H‐Chromenes in Water

Key Points

The aim is to develop an efficient and environmentally friendly method for synthesizing 2-amino-4H-chromenes using itaconic acid.
Utilized itaconic acid as a catalyst in aqueous media.
Reacted various functionalized aromatic aldehydes with malononitrile and α/β-naphthol.
Optimized reaction conditions to maximize yield and efficiency.
Achieved excellent yields of 2-amino-4H-chromene derivatives.
Demonstrated broad substrate scope and high efficiency.
Recyclability of the catalyst was excellent, reducing waste.

Abstract

ABSTRACT The synthesis of 2‐amino‐4H‐chromenes is described using itaconic acid as a catalyst in aqueous media. Under optimized reaction conditions, a variety of functionalized aromatic aldehydes, malononitrile, and α/β‐naphthol were reacted to afford 2‐amino‐4H‐chromene derivatives in excellent yields. This method is notable for its broad substrate scope, short reaction time, high efficiency, functional group tolerance, operational simplicity, and excellent catalyst recyclability. This makes the protocol feasible, economical, and environmentally benign.

Bookmark

Cite This Study

SHELAR et al. (Wed,) studied this question.

synapsesocial.com/papers/69e1cf375cdc762e9d858292 https://doi.org/https://doi.org/10.1002/slct.202507376

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Bookmark