Serum metabolomic profile in children with sepsis-associated acute kidney injury

Key Points

• This research aims to explore the use of serum metabolomics for identifying biomarkers in children with sepsis-associated acute kidney injury.
• Analyzed serum metabolomic profiles in children with sepsis and acute kidney injury.
• Compared metabolite levels between AKI cases and sepsis controls.
• Assessed correlations between metabolite levels and clinical severity using estimated glomerular filtration rate.
• Phosphoethanolamine metabolites effectively distinguish AKI cases from sepsis controls.
• These metabolites correlate with the decline in glomerular filtration rate, indicating their prognostic value.
• The diagnostic approach needs further validation in larger, multicenter cohorts.