A click-crosslinked dopamine-functionalized hydrogel for therapeutic delivery of stem cell-derived extracellular vesicles

Key Points

• The aim is to investigate the use of a dopamine-functionalized hydrogel for the delivery of extracellular vesicles to enhance tissue regeneration.
• Developed a dopamine-functionalized hyaluronic acid hydrogel (Dopa-HA) using click-crosslinking techniques.
• Assessed the hydrogel's ability to sustain and localize the delivery of extracellular vesicles.
• Evaluated the effectiveness of Dopa-HA in promoting tissue regeneration.
• Dopa-HA provided sustained release of extracellular vesicles over time.
• The hydrogel demonstrated effectiveness in supporting tissue regeneration processes.