Improved dietary control results in improvements in indices of white matter structure in adults with phenylketonuria: the ReDAPT study

Key Points

• To evaluate the impact of dietary control on white matter structure in adults with phenylketonuria (PKU).
• Evaluated neuroimaging measures over a 12-month period.
• Monitored dietary control and Phe levels in PKU patients.
• Assessed T1w/T2w ratio as a marker of white matter integrity.
• Significant increases in T1w/T2w ratios were observed with improved dietary control.
• Raw Phe levels did not show strong associations with neuroimaging measures.
• Findings support ongoing treatment for PKU and suggest reversibility of white matter changes.