Introduction- Ayurveda, the ancient system of medicine, is founded on a holistic understanding of health, emphasizing the balance of body, mind, and spirit. In the current era of evidence-based medicine, there is a growing need to scientifically validate Ayurvedic principles and therapeutic practices. Ayurvedic research methodology, known as Anusandhan Paddhati, integrates classical epistemological concepts with modern scientific approaches, providing a distinctive and comprehensive framework for health research. This integration is essential for establishing the credibility and wider acceptance of Ayurveda in global healthcare. Methods- This study adopts a conceptual and analytical approach to explore Ayurvedic research methodology. Core classical principles Pratyaksha (direct perception), Anumana (inference), Aptopadesha (authoritative testimony), and Yukti (logical reasoning) were critically examined and compared with contemporary scientific research methods. Data were derived from classical Ayurvedic texts and relevant modern scientific literature to understand their applicability in research design, data interpretation, and validation processes. Results- The findings indicate that Ayurvedic research methodology offers a multidimensional and integrative framework that complements modern scientific methods. The incorporation of classical epistemological tools enhances the depth, reliability, and validity of research outcomes. Additionally, Ayurveda’s emphasis on individualized assessment and holistic evaluation provides insights often overlooked in conventional biomedical research models. Discussion- The study underscores the necessity of developing standardized and integrative research models that harmonize Ayurvedic principles with modern scientific protocols. Such an approach can enhance reproducibility, strengthen scientific evidence, and improve global acceptance of Ayurveda. Advancing methodological frameworks will not only support evidence-based validation but also facilitate the integration of Ayurveda into mainstream healthcare systems.
K et al. (Fri,) studied this question.