ABSTRACT Background TONSL is involved in various biological processes such as maintaining genomic stability and promoting tumor progression. Aims The purpose of this article is to comprehensively clarify the expression of TONSL in Pan‐Cancer, explore the association between TONSL expression and tumor tissues, prognosis, and immune infiltration in the tumor microenvironment, and clarify the interaction and combined effect between TONSL and MMS22L. This will further provide more precise targets and strategies for tumor treatment. Methods and Results Methods for evaluating immune‐infiltration based on genomics and transcriptomics have become a popular area of research. This study found that TONSL is often overexpressed in tumor tissues and is linked to a poor prognosis. TONSL expression can impact immune infiltration in the tumor microenvironment and subsequently affect tumor prognosis. TONSL can interact with MMS22L to have a combined effect. Conclusion These findings shed light on TONSL expression in Pan‐Cancer comprehensively and provide more precise targets and strategies for tumor therapy.
Yang et al. (Wed,) studied this question.